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Fatih Bingöl
Erzurum Eğitim ve Araştırma...
Buket Özel Bingöl
Erzurum Eğitim ve Araştırma...
Korhan Kılıç
Erzurum Eğitim ve Araştırma...
İlknur Çalık
Erzurum Eğitim ve Araştırma...
Eda Şimşek
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ANCIENT SCHWANNOMA AND POSTOPERATIVE HORNER’S SYNDROME DERIVING FROM THE ANSA CERVICALIS

ANCIENT SCHWANNOMA AND POSTOPERATIVE HORNER’S SYNDROME DERIVING FROM THE ANSA CERVICALIS
Articles > Head and Neck Surgery
Submitted : 01.07.2016
Accepted : 12.12.2016
Published : 12.12.2016

Abstract

Schwannoma is a rare tumor arising from the peripheral nerve sheath. Ancient schwannoma is a rare, slow-growing variant. In this report we presented a rare case with ancient schwannoma of symphatetic nerves of the neck which caused postoperative Horner Syndrome. To our knowledge, there is only a few reports about ancient schwannoma of sympatetic nerves in English literature. Because of possible complications of surgery of schwannomas such as Horner Syndrome, it must be kept in mind in the differential diagnosis of lateral neck masses.

Introduction

Schwannoma is a rare tumor arising from the peripheral nerve sheath. It frequently occurs in the head and neck region and the extremities. Schwannomas in the head and neck region generally derive from the cervical sympathetic nerve and the nervus vagus[1]. Ancient schwannoma is a rare, slow-growing variant. The term ‘ancient’ was first used by Ackerman and Taylor to indicate the prolonged course of degenerative changes in the appearance of this entities [2].

It generally occurs as a slow-growing, painless, benign mass in the neck [3]. Malign transformation may be seen together with Von Recklinghausen disease[4]. In some advanced cases, symptoms such as cough, dysphagia, cranial nerve paralyses, Horner’s syndrome and hearing loss may result from pressure on surrounding structures. In this report we presented a rare case with ancient schwannoma of symphatetic nerves of the neck which caused postoperative Horner Syndrome [5]. [ ]To our knowledge, there is only a few reports about ancient schwannoma of sympatetic nerves in English literature.  

Case Report

A 17-year-old male presented to our clinic with a painless swelling in the upper right part of the neck existing for approximately two years. Otorhinolaryngological examination revealed a well-marginated, pulsatile mass, 6.5 cmin size, beneath the right corner of the mandible. The pharynx was displaced medially. Ultrasonography was performed which revealed a heterogenic hypoechoic mass differentiated from surrounding tissue with good margins containing cystic areas, 9x5 cm in size, neighboring on the carotid. A mass well differentiated from heterogeneously contrasting surrounding tissue was observed on post-contrast images at computerized tomography (CT) of the neck.

Figure 1
Radiological examination of the mass.A: Contrast enhanced CT showed a mass well differentiated from heterogeneously contrasting surrounding tissue


At magnetic resonance imaging (MRI) of the neck, a solid mass exhibiting abundant vacuolization displacing the carotis  interna and internal jugular vein in a lateral direction with cystic spaces, hypointense on T1 weighted images and hyperintense on T2 weighted images, was observed.

Figure 2
T1 weighted MRI showed hypointense mass exhibiting abundant vacuolization displacing the carotis interna and internal jugular vein in a lateral direction. T2 weighted MRI showed hyperintense mass with cystic spaces.


Fine needle aspiration biopsy of the mass was reported as negative for malignancy. Total excision of the mass was performed with a trans-cervical approach under general anesthesia. During surgery, the neurovascular bundle was identified as we entered through the anterior margin of the sternocleidomastoid muscle. The mass was located immediately beneath the neurovascular bundle in the inferior part of the carotid artery bifurcation . The mass had regular margins and was easily differentiated from surrounding tissues. It was separated from the neighboring tissue and the neurovascular bundle, and was seen to derive from the cervical sympathetic chain. The mass was completely excised (Figure 3-A). At histopathological examination, cellular Antoni-A areas containing Verocay bodies consisting of cells with spindle-oval shaped nuclei and hypocellular Antoni-B areas were observed. Diffuse hyaline degeneration and calcification in the stroma and thrombosed vascular structures were seen. No mitosis was observed. At immunohistochemical investigation, S-100 was diffuse, strongly positive and CD56 was focal positive, while CD34, desmin and SMA were negative. A chi-67 proliferation index of 3-5% was determined. Ancient schwannoma was diagnosed in the light of the existing data.

Figure 3
The appearances of the mass. A: Totally excised mass B: Antoni A and Antoni B areas including Verocay bodies. C: Diffuse, strong S-100 positivity. (S100x200)


Horner’s syndrome characterized by ptosis, miosis and enophthalmos on the right side developed in the postoperative period. No recurrence was observed during 4-month follow-up, and the Horner’s syndrome resolved.

Discussion

Schwannomas are benign, encapsulated tumors deriving from Schwann cells in the peripheral nerve sheath. Schwannomas are typically solitary, encapsulated tumors gradually extending outside the fibrils from which they originate. Histopathologically, they consist of varying proportions of Antoni-A and Antoni-B cell patterns. Antoni-A areas consist of palisading sequences of compact spindle-shaped cells, while Antoni-B areas are loose hypocellular regions. Necrosis and cystic degeneration, hyalinization and calcification may be seen in the stroma[6]. In histological terms, five schwannoma variants have been described; common, plexiform, cellular, epithelioid, and ancient schwannomas [7]. The term ancient is used in order to describe the tumor’s gradual degenerative changes, diffuse hypocellular areas, nuclear hyperchromasia and pronounced nuclear atypia [3].

Schwannomas are found in the lateral region of the neck. They constitute encapsulated tumors that are horizontally mobile but vertically immobile and that may sometimes lead to displacement in the lateral pharyngeal wall[8]. Ancient schwannomas are rare and particularly prevalent in elderly subjects[6]. They generally emerge in the 3[rd] and 4[th] decades, as slow-growing, painless masses. They may cause symptoms through the pressure they place on surrounding tissues[9]. In some advanced cases this pressure on neighboring tissues may result in symptoms such as cough, dysphagia, cranial nerve paralyses, Horner’s syndrome and loss of hearing [10].

Radiological findings in ancient schwannomas are similar to those in other schwannomas. At ultrasonography they appear as hypoechoic masses with regular margins, and calcifications may be determined. CT and MRI can assist with the diagnosis of schwannoma. At contrast enhanced CT they appear as a mass differentiated with well-defined margins from heterogeneously contrasting surrounding tissues. Isobe et al. suggested that MRI is of greater usefulness. Schwannoma is generally hypointense on T1 weighted MRI images and hyperintense on T2 weighted images [11].

Schwannomas are radioresistant tumors. Treatment essentially consists of surgery. In terms of surgical technique, the ideal approach is dissection with protection of the nerve. Total excision was performed in our case, with a transcervical approach. The mass was dissected from surrounding tissues and the neurovascular bundle[12].  After excision, permanent or gradually resolving sequelae such as Horner’s syndrome may persist [13].  Postoperative Horner’s syndrome developed in our case. However, this resolved during 4-month follow-up.

Conclusion

Ancient schwannoma of cervical sympathetic chain is very rare disease with only a few reports in English literature. Because of possible complications of surgery of schwannomas such as Horner Syndrome, it must be kept in mind in the differential diagnosis of lateral neck masses. 

References

  1. Chang SC, & Schi YM. Neurilemmoma of the vagus nerve. A case report and brief literature review. Laryngoscope 1984;94(7): 946-949.
  2. Ackerman LV, Taylor FH. Neurogenous tumors within the thorax. A clinicopathological evaluation of forty‐eight cases. Cancer 1951; 4(4): 669-691.
  3. Rath S, et al. Ancient Schwannoma of Ansa Cervicalis: A Rare Clinical Entity and Review of the Literature. Case Rep Surg, 2015.
  4. Sharma SK, et al. Retroperitoneal Schwannoma Mimicking An Adrenal Lesion.  World J Urol 2002;20(4): 232-233.
  5. Keleş E, et al. Üst Servikal Sempatik Zincirden Kaynaklanan Periferik Parafarengeal Schwannoma: Olgu Sunumu. In KBB-Forum 200;5:54-7.
  6. Hide IG, et al. Giant ancient schwannoma of the pelvis. Skeletal Radiol 2000; 29(9): 538-542.
  7. Weiss SW, Goldblum JR. Parotis schwannoma. In: Enzinger SW, Weiss SW, editors. Enzinger and Weiss’s Soft Tissue Tumors. 4th ed. Mosby: Saint Louis Missoury; 2001. p.1146–67.
  8. Reddıck LP, Myers RT. Nerilemmoma of The Cervical Portion of The Vagus Nerve. A Collective Review and Two Case Reports. Am J Surg. 1973:125:744-747.
  9.  Valentino J, et al. Expected neurologic outcomes for surgical treatment of cervical neuriiemmomas. Laryngoscope 1998;108:1009-23
  10. Kahraman A, et al. Horner's syndrome from giant schwannoma of the cervical sympathetic chain: case report. B-ENT, 2009;5(2):111.
  11. Moukarbel RV, Sabri AN. Current management of head and neck schwannomas. Curr Opin Otolaryngol Head Neck Surg 2005: 13; 117-122.
  12. Isobe K, et al. Imaging of ancient schwannoma. Am J Roentgenol 2004;183(2): 331-336.
  13. De Araujo CEN, et al. Neck nerve trunks schwannomas: clinical features and postoperative neurologic outcome.  Laryngoscope, 2008; 118(9): 1579-1582.
Keywords : Ancient Schwannoma , Ansa Servikalis , Horner Sendromu

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